七旬老伯重症肺炎险丧命,二代测序助力医生揪元凶
2021-03-30 患者胡言乱语、吵闹好转,心理科会诊考虑抑郁状态,继续奥氮平2.5mg qd,仍夜间烦躁,睡眠欠佳,加用思诺思10mg qn。2021-03-31 血mNGS回报:鹦鹉热衣原体核酸序列246条。 ![](/img.php?url=https://img04.71396.com/ba/cg/1e864a14f555d53d.jpg)
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- 2021-03-31 体温平,气促稍好转,考虑患者鹦鹉热衣原体感染,合并细菌感染可能不除外,调整为哌拉西林钠/他唑巴坦4.5g q8h ivgtt+多西环素0.1g q12h po++阿奇霉素0.25g qd ivgtt。
- 2021-04-02 血培养回报(03-27留取):阴性。
- 2021-04-02起患者体温转平,咳嗽气急症状逐渐好转。2021-04-03复查血WBC 6.69X10^9/L,N 86.3%,hs-CRP 78.3mg/L,ESR 40mm/H,PCT 0.45ng/ml;ALT/AST 48/47U/L;2021-04-06复查血WBC 6.17X10^9/L,N 79.8%,hs-CRP 26.5mg/L,ESR 20mm/H,PCT 0.29ng/ml;ALT/AST 58/79U/L。
- 2021-04-12 体温平,无咳嗽咳痰,无明显气急,精神可,夜间睡眠可,复查 PaO2(鼻导管3L/min):102mmHg,WBC 4.16X10^9/L,N 62.3%,hs-CRP 21.8mg/L,ESR 14mm/H,PCT 0.18ng/ml;ALT/AST 33/23U/L,较前明显好转。胸部CT平扫:右肺病灶范围较前缩小,病灶变淡。停哌拉西林钠/他唑巴坦,继续多西环素0.1g q12h po+阿奇霉素0.25g qd po口服,予出院。
出院后随访
- 患者出院后继续多西环素+阿奇霉素口服,未再发热,无咳嗽咳痰;
- 2021-04-29 门诊复查 WBC 4.83X10^9/L,N 61.1%;ESR 9mm/H,hsCRP 0.9mg/L,PCT 0.08ng/ml;生化:ALT/AST 13/19 U/L。胸部CT:右肺炎症较2021-4-12进一步吸收好转。予停用抗感染药物。
治疗前后胸部CT变化情况
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治疗前后体温变化情况
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炎症标志物变化情况
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五、最后诊断与诊断依据
最终诊断
- 社区获得性肺炎(鹦鹉热衣原体,重症肺炎)