亚型四：占比19%，tau蛋白在左半球不对称扩散，主要影响语言能力。
3篇《柳叶刀》：糖尿病和认知障碍的联系千丝万缕，合并疾病需有效管理
神经系统损害是糖尿病常见的慢性并发症，糖尿病患者发生认知障碍和痴呆症风险也会增加。《柳叶刀》“糖尿病与大脑健康”系列中，3篇不同角度的研究阐述了中枢神经系统与胰岛素调节的复杂相互作用，以及高危人群的筛查和防治。
简单验血高效诊断阿尔茨海默病，《柳叶刀-神经病学》发表重要进展
研究显示，通过血液检测p-tau217和p-tau181两种标志物，能够高效诊断阿尔茨海默病，并能够区分阿尔茨海默病与FTLD等其他神经退行性疾病。与PET等复杂影像学检测相比，血液检测更容易获得、可推广。
研究团队表示，“我们使用的检测目前仅限用于研究，但希望在几年内，有机会可推广用于临床。”
参考资料
[1] 世界没有解决痴呆症问题. Retrieved September 18, 2021, from
https://www.who.int/zh/news/item/02-09-2021-world-failing-to-address-dementia-challenge
[2] Gill Livingston, et al., (2020). Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet, DOI: 10.1016/S0140-6736(20)30367-6
[3] Mika Kivimäki, et al., (2021). Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies. BMJ, DOI: 10.1136/bmj.n1804
[4] Elisabeth H Thijssen, et al., (2021). Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study, DOI: https://doi.org/10.1016/S1474-4422(21)00214-3
[5] Vogel, J.W., Young, A.L., Oxtoby, N.P. et al. Four distinct trajectories of tau deposition identified in Alzheimer’s disease. Nat Med (2021). https://doi.org/10.1038/s41591-021-01309-6
[6] Longfei Jia, et al., (2020). Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. The Lancet Public Health, DOI: https://doi.org/10.1016/S2468-2667(20)30185-7
